Regulation of Illegal Drugs – No Longer “What”?, but “How”?

Not if but when; no longer why but how

There is accruing evidence that information technology can improve patient health care, with several trials of technology showing smaller numbers of medication errors, or can provide earlier detection of adverse events. Critics of this type of research point out that better resolution of events is of no value unless their direct management influences clinical outcome. Nevertheless, indirect evi...

Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer 'if' but 'how'.

The central nervous system (CNS) tissues, including the brain, the eye, and the spinal cord, are immune-privileged, secluded from the circulation by a complex of barriers, and equipped with their own myeloid cell population, the resident microglia. Based on the classical perspective of immune-brain interactions and on the contribution of such interactions to the progression of multiple sclerosi...

Cholesterol and cardiovascular disease: no longer whether, but rather when, in whom, and how?

Hairless but no longer clueless: understanding glandular trichome development

Glandular trichomes are remarkable biochemical factories that produce a wealth of secondary metabolites important for plant defenses against herbivores. However, little is known about their developmental biology. Studying the tomato hairless mutant, which develops distorted glandular trichomes and has compromised metabolic and defense capacity, Kang et al. (pages 5313–5324 in this issue) showed...

Intestinal stem cells: no longer immortal but ever so clever....

To maintain tissue homeostasis, stem cells must balance self-renewal with differentiation. In some stem cell lineages this process is 'hard-wired' by the asymmetric partitioning of determinants at division, such that one stem cell daughter always remains pluripotent and other differentiates. But in a dynamic tissue like the intestinal epithelium, which might need to repair itself following an i...